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A further nebulised antibiotic used for remedy of cystic fibrosis infections is tobramycin, an aminoglycoside antibiotic with equivalent chemical construction to amikacin. It truly is for that reason possible that by combining manuka honey and tobramycin enhanced antimicrobial exercise against M. abscessus
which eventually brought about lack of membrane integrity (Rabie et al., 2016). Although the mechanism of action behind manuka honeys antimicrobial exercise hasn't nevertheless been completely elucidated, the presence of methylglyoxal suggests that bacterial cell membrane disruption is probably going to generally be one of several top contributing components.
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